DMW - Deutsche Medizinische Wochenschrift, Table of Contents Dtsch Med Wochenschr 2006; 131(42): 2355-2358DOI: 10.1055/s-2006-955016 Prinzip & Perspektive | Review articleGrundlagenforschung© Georg Thieme Verlag KG Stuttgart · New YorkCD8+ T-Zelldifferenzierung bei VirusinfektionenCD8+ T cell differentiation in viral infectionsB. Bengsch1 , R. Thimme1 1Abteilung Innere Medizin II, Universitätsklinik Freiburg Recommend Article Abstract Buy Article Schlüsselwörter CD8+ T-Zellen - Virusinfektionen - Immunpathogenese Key words CD8+ T cells - viral infections - immunopathogenesis Full Text References Literatur 1 Appay V, Dunbar P R, Callan M. et al . Memory CD8+ T cells vary in differentiation phenotype in different persistent virus infections. Nat Med. 2002; 8 379-385 2 Barber D L, Wherry E J, Masopust D. et al . Restoring function in exhausted CD8 T cells during chronic viral infection. Nature. 2006; 439 682-687 3 Boettler T, Panther E, Bengsch B. et al . Expression of IL-7 receptor a chain (CD127) on virus-specific CD8+ T cells identifies functionally and phenotypically defined memory T cells in acute resolving hepatitis B virus infection. J Virol. 2006; 80 3532-3540 4 Gattinoni L, Klebanoff C A, Palmer D C. et al . Acquisition of full effector function in vitro paradoxically impairs the in vivo antitumor efficacy of adoptively transferred CD8+ T cells. J Clin Invest. 2005; 115 1616-1626 5 Kaech S M, Tan J T, Wherry E J, Konieczny B T, Surh C D, Ahmed R. Selective expression of the interleukin 7 receptor identifies effector CD8 T cells that give rise to long-lived memory cells. Nat Immunol. 2003; 4 1191-1198 6 Klenerman P, Hill A. T cells and viral persistence: lessons from diverse infections. Nat Immunol. 2005; 6 873-879 7 McMichael A J, Rowland-Jones S L. Cellular immune responses to HIV. Nature. 2001; 410 980-987 8 Rehermann B, Nascimbeni M. Immunology of hepatitis B virus and hepatitis C virus infection. Nat Rev Immunol. 2005; 5 215-229 9 Schmitz J E, Kuroda M J, Santra S. et al . Control of viremia in simian immunodeficiency virus infection by CD8+ lymphocytes. Science. 1999; 283 857-860 10 Shoukry N H, Grakoui A, Houghton M. et al . Memory CD8+ T cells are required for protection from persistent hepatitis C virus infection. J Exp Med. 2003; 197 1645-1655 11 Thimme R, Wieland S, Steiger C. et al . CD8(+) T cells mediate viral clearance and disease pathogenesis during acute hepatitis B virus infection. J Virol. 2003; 77 68-76 12 Thimme R, Appay V, Koschella M. et al . Increased expression of the NK cell receptor KLRG1 by virus-specific CD8 T cells during persistent antigen stimulation. J Virol. 2005; 79 12112-12116 13 Thimme R, Lohmann V, Weber F. A target on the move: Innate and adaptive immune escape strategies of hepatitis C virus. Antiviral Res. 2006; 69 129-141 14 van Leeuwen E M, de Bree G J, Remmerswaal E B. et al . IL-7 receptor alpha chain expression distinguishes functional subsets of virus-specific human CD8+ T cells. Blood. 2005; 106 2091-2098 Prof. Dr. med. Robert Thimme Universitätsklinikum Freiburg, Abteilung Innere Medizin II Hugstetter Straße 55 79106 Freiburg Phone: 0761/2703280 Fax: 0761/2703372 Email: thimme@med1.ukl.uni-freiburg.de